Mortality and survival patterns of people living with HIV-2
Identifieur interne : 000F10 ( Main/Exploration ); précédent : 000F09; suivant : 000F11Mortality and survival patterns of people living with HIV-2
Auteurs : Boris Tchounga [France] ; Didier K. Ekouevi [France] ; Eric Balestre [France] ; François Dabis [France]Source :
- Current opinion in HIV and AIDS [ 1746-630X ] ; 2016.
Abstract
People living with HIV-2 infected usually initiate antiretroviral therapy (ART) at an advanced period in the course of their infection after a long asymptomatic period characterized by high CD4 cell count and thus at a relatively advanced age. In the new international context of early and universal ART initiation, the aim was to review survival patterns among HIV-2 infected patients, either on ART or not.
Very few reports were published on mortality in people living with HIV-2 during the last five years. People living with HIV-2 experience high mortality rates although lower than people living with HIV-1 before ART initiation. They seem to survive longer regardless of the conditions of ART use. Mortality is associated with late presentation, male gender, CD4 count <500 cell/μl, high plasma viral load, hemoglobin rate <8 g/dl) and body mass index < 18 Kg/m2.
People living with HIV-2 initiate ART later than HIV-1 and HIV duals, resulting in higher disease progression and mortality rate. The clinical management of HIV-2 infected patients should now include early diagnosis and treatment initiation as per international guidelines. Further research needs to explore the “what to start” question and document specific causes of death in people living with HIV-2 and enrolled in care in Africa.
Url:
DOI: 10.1097/COH.0000000000000299
PubMed: 27254747
PubMed Central: 5055442
Affiliations:
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In the new international context of early and universal ART initiation, the aim was to review survival patterns among HIV-2 infected patients, either on ART or not.</p></sec><sec id="S2"><title>Recent findings</title><p id="P2">Very few reports were published on mortality in people living with HIV-2 during the last five years. People living with HIV-2 experience high mortality rates although lower than people living with HIV-1 before ART initiation. They seem to survive longer regardless of the conditions of ART use. Mortality is associated with late presentation, male gender, CD4 count <500 cell/μl, high plasma viral load, hemoglobin rate <8 g/dl) and body mass index < 18 Kg/m<sup>2</sup>.</p></sec><sec id="S3"><title>Summary</title><p id="P3">People living with HIV-2 initiate ART later than HIV-1 and HIV duals, resulting in higher disease progression and mortality rate. The clinical management of HIV-2 infected patients should now include early diagnosis and treatment initiation as per international guidelines. Further research needs to explore the “what to start” question and document specific causes of death in people living with HIV-2 and enrolled in care in Africa.</p></sec></div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement><orgName><li>Université de Bordeaux</li></orgName></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tchounga, Boris" sort="Tchounga, Boris" uniqKey="Tchounga B" first="Boris" last="Tchounga">Boris Tchounga</name></region><name sortKey="Balestre, Eric" sort="Balestre, Eric" uniqKey="Balestre E" first="Eric" last="Balestre">Eric Balestre</name><name sortKey="Balestre, Eric" sort="Balestre, Eric" uniqKey="Balestre E" first="Eric" last="Balestre">Eric Balestre</name><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="François" last="Dabis">François Dabis</name><name sortKey="Ekouevi, Didier K" sort="Ekouevi, Didier K" uniqKey="Ekouevi D" first="Didier K" last="Ekouevi">Didier K. Ekouevi</name><name sortKey="Ekouevi, Didier K" sort="Ekouevi, Didier K" uniqKey="Ekouevi D" first="Didier K" last="Ekouevi">Didier K. Ekouevi</name><name sortKey="Tchounga, Boris" sort="Tchounga, Boris" uniqKey="Tchounga B" first="Boris" last="Tchounga">Boris Tchounga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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